What is Atopic Dermatitis?

This diagram, presented at ETP Day 2014 by Prof. Christine Bodemer, summarizes current knowledge of the evolution of atopic dermatitis, and indicates the position of various genetic and environmental factors that play a role in this development.

FCER1A : cellular receptor for IgE

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Role-players in atopic dermatitis and its development

Allergens

Secondary

infections

Excoriations, ...

Auto-inflammatory

dermatitis

Sensitization

Atopic

Dermatitis

Auto-Sensitization

Autoallergic

dermatitis

AsthmaRhinitis…

Altered epidermal barrier

FCER1A

Receptor

Cytokines

Tissue genes

“Immuno-allergic” genes

receptors, cytokines