Clinical signs
Histological section
(but in practice a biopsy is rarely necessary)
Normal
Erythematous phase
Vesicular phase
Oozing phase
Desquamative phase
EPIDERMIS
DERMIS
EPIDERMIS
DERMIS
Early
spongiosis
Acanthosis
EPIDERMIS
DERMIS
Exocytosis
Blisters filled with
clear liquid
Early
spongiosis
Acanthosis
Rupture
of the blisters
EPIDERMIS
DERMIS
Infected blister
Exocytosis
Blisters filled with
clear liquid
Early
spongiosis
Acanthosis
Rupture
of the blisters
Healing
Spongiose
EPIDERMIS
DERMIS
Desquamation
Infected blister
Exocytosis
Blisters filled with
clear liquid
Early
spongiosis
Acanthosis